Abstract
Two new holostan-type glycosides, holotoxin D1 (1) and 25,26-dihydroxy-holotoxin A1 (2), together with two known analogues, stichlorosides C1 (3) and bivittoside D (4), were isolated from the sea cucumber Apostichopus japonicus Selenka. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis. Glycosides 1 and 3 exhibited potent antifungal activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Glycosides / chemistry
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Glycosides / isolation & purification
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Microbial Sensitivity Tests
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Molecular Structure
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Sea Cucumbers / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
Substances
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Antifungal Agents
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Glycosides
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Triterpenes