Water-soluble and pH-responsive polymeric nanotubes from cyclic peptide templates

Robert Chapman; Gregory G Warr; Sébastien Perrier; Katrina A Jolliffe

doi:10.1002/chem.201203602

Water-soluble and pH-responsive polymeric nanotubes from cyclic peptide templates

Chemistry. 2013 Feb 4;19(6):1955-61. doi: 10.1002/chem.201203602. Epub 2013 Jan 7.

Authors

Robert Chapman¹, Gregory G Warr, Sébastien Perrier, Katrina A Jolliffe

Affiliation

¹ School of Chemistry (Building F11), The University of Sydney, NSW, 2006, Australia.

PMID: 23297172
DOI: 10.1002/chem.201203602

Abstract

Water-soluble organic nanotubes were prepared by convergently conjugating polymers of hydroxyethyl acrylate (HEA) and acrylic acid (AA) to self-assembling cyclic octapeptides of alternating D and L chirality. The structure of the self-assembled tubes was characterised in a number of polar solvents, and notably water, by using light scattering, TEM and small angle neutron scattering (SANS) techniques. In addition, the self-assembly into tubes could be controlled by exploiting the pH responsiveness of acrylic acid polymers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylates / chemistry*
Hydrogen-Ion Concentration
Nanotubes / chemistry*
Peptides, Cyclic / chemistry*
Polymers / chemistry*
Solvents
Water / chemistry*

Substances

Acrylates
Peptides, Cyclic
Polymers
Solvents
Water