Ras GTPases: codon bias holds KRas down but not out

Curr Biol. 2013 Jan 7;23(1):R17-20. doi: 10.1016/j.cub.2012.11.054.

Abstract

Rare codons selectively limit the accumulation of Ras family member proteins with important consequences for Ras pathway activation and tumorigenesis.

Publication types

  • Comment

MeSH terms

  • Cell Transformation, Neoplastic / genetics*
  • Codon*
  • Genes, ras*
  • Humans
  • Proto-Oncogene Proteins / chemistry*
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins / chemistry*

Substances

  • Codon
  • KRAS protein, human
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins