Mixed neuroendocrine tumor of the common bile duct

Revital Linder; Tatiana Dorfman; Offir Ben-Ishay; Eli Kakiashvili; Eugene Velodavsky; Yoram Kluger

doi:10.6092/1590-8577/1225

Mixed neuroendocrine tumor of the common bile duct

JOP. 2013 Jan 10;14(1):71-3. doi: 10.6092/1590-8577/1225.

Authors

Revital Linder¹, Tatiana Dorfman, Offir Ben-Ishay, Eli Kakiashvili, Eugene Velodavsky, Yoram Kluger

Affiliation

¹ Division of Surgical Oncology, Department of General Surgery, Rambam Health Care Center, Haifa, Israel.

PMID: 23306338
DOI: 10.6092/1590-8577/1225

Abstract

Context: Mixed adenoendocrine tumors of the extrahepatic bile ducts are exceedingly rare and most of those who are rarely diagnosed are adenocarcinomas. Neuroendorine tumors accounts for only 0.2-2%.

Case report: We report a case of mixed adenoneuroendo-carcinoma of the common bile duct in an 82-year-old male.

Conclusion: Clinical experience suggests that the neuroendocrine component of mixed tumors behave more aggressively than the regular biliary adenocarcinoma component. This clinical behavior may have an important role in the management of this clinical entity.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / diagnosis
Adenocarcinoma / metabolism
Adenocarcinoma / surgery
Aged, 80 and over
Chromogranin A / analysis
Common Bile Duct / chemistry
Common Bile Duct / pathology*
Common Bile Duct / surgery
Common Bile Duct Neoplasms / diagnosis*
Common Bile Duct Neoplasms / metabolism
Common Bile Duct Neoplasms / surgery
Humans
Immunohistochemistry
Male
Mixed Tumor, Malignant / diagnosis*
Mixed Tumor, Malignant / metabolism
Mixed Tumor, Malignant / surgery
Neuroendocrine Tumors / diagnosis*
Neuroendocrine Tumors / metabolism
Neuroendocrine Tumors / surgery
Synaptophysin / analysis
Treatment Outcome

Substances

Chromogranin A
Synaptophysin