Condensin, cohesin and the control of chromatin states

Curr Opin Genet Dev. 2013 Apr;23(2):204-11. doi: 10.1016/j.gde.2012.11.004. Epub 2013 Jan 9.

Abstract

Cohesin and condensin complexes are essential for defining the topology of chromosomes through the cell cycle. Here we look at the emerging role of these complexes in regulating chromatin structure and gene expression and reflect on how these activities could be linked with chromosome topology.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / genetics
  • Adenosine Triphosphatases / metabolism*
  • Animals
  • Cell Cycle
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Chromatin / genetics
  • Chromatin / ultrastructure*
  • Chromosomal Proteins, Non-Histone / genetics
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Chromosome Structures
  • Chromosomes / genetics
  • Chromosomes / ultrastructure*
  • Cohesins
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Eukaryota* / cytology
  • Eukaryota* / genetics
  • Gene Expression Regulation
  • Humans
  • Mitosis / genetics
  • Multiprotein Complexes / genetics
  • Multiprotein Complexes / metabolism*

Substances

  • Cell Cycle Proteins
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Multiprotein Complexes
  • condensin complexes
  • Adenosine Triphosphatases