Abstract
This is the first investigation of MMPs in children with febrile seizures. In a prospective, cross sectional study, serum levels of matrix metalloproteinases (MMP8/9), tissue inhibitor of metalloproteinases (TIMP1/2), of children with FS (n=13), children with febrile infection (FI, n=13) and children with unprovoked generalized seizures (US, n=11) were compared. Neither provoked nor unprovoked seizures in FS and US seem to elevate levels of MMPs or TIMPs, whereas in case of febrile infection blood level of MMP8 was significant elevated. Seizures in general might have no influence on this distinctive inflammatory process or even might have suppressive impact.
Copyright © 2012 Elsevier B.V. All rights reserved.
MeSH terms
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Biomarkers / blood
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Child
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Child, Preschool
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Cross-Sectional Studies
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Cytokines / blood*
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Epilepsy / blood
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Epilepsy / etiology
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Epilepsy / pathology*
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Female
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Humans
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Infant
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Inflammation Mediators / blood*
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Inflammation Mediators / physiology
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Male
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Matrix Metalloproteinase 8 / blood*
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Matrix Metalloproteinase 8 / physiology*
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Prospective Studies
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Seizures / blood
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Seizures / diagnosis
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Seizures / pathology
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Seizures, Febrile / blood*
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Seizures, Febrile / etiology
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Seizures, Febrile / pathology*
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Tissue Inhibitor of Metalloproteinase-1 / blood
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Tissue Inhibitor of Metalloproteinase-2 / blood
Substances
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Biomarkers
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Cytokines
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Inflammation Mediators
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TIMP1 protein, human
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TIMP2 protein, human
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Tissue Inhibitor of Metalloproteinase-1
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Tissue Inhibitor of Metalloproteinase-2
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MMP8 protein, human
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Matrix Metalloproteinase 8