Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains

Vaccine. 2013 Feb 18;31(9):1298-304. doi: 10.1016/j.vaccine.2012.12.076. Epub 2013 Jan 9.

Abstract

Six different adjuvants, each in combination with inactivated polio vaccine (IPV) produced with attenuated Sabin strains (sIPV), were evaluated for their ability to enhance virus neutralizing antibody titres (VNTs) in the rat potency model. The increase of VNTs was on average 3-, 15-, 24-fold with adjuvants after one immunization (serotypes 1, 2, and 3, respectively). Also after a boost immunization the VNTs of adjuvanted sIPV were on average another 7-20-27 times higher than after two inoculations of sIPV without adjuvant. The results indicate that it is feasible to increase the potency of inactivated polio vaccines by using adjuvants.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage*
  • Animals
  • Antibodies, Neutralizing / blood
  • Antibodies, Viral / blood
  • Neutralization Tests
  • Poliovirus / immunology*
  • Poliovirus Vaccine, Inactivated / administration & dosage
  • Poliovirus Vaccine, Inactivated / immunology
  • Poliovirus Vaccines / administration & dosage*
  • Poliovirus Vaccines / immunology*
  • Rats

Substances

  • Adjuvants, Immunologic
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Poliovirus Vaccine, Inactivated
  • Poliovirus Vaccines