ZrCl2(η-C5Me5)2-AlHCl2·(THF)2: efficient hydroalumination of terminal alkynes and cross-coupling of the derived alanes

Philip Andrews; Christopher M Latham; Marc Magre; Darren Willcox; Simon Woodward

doi:10.1039/c2cc37537k

ZrCl2(η-C5Me5)2-AlHCl2·(THF)2: efficient hydroalumination of terminal alkynes and cross-coupling of the derived alanes

Chem Commun (Camb). 2013 Feb 21;49(15):1488-90. doi: 10.1039/c2cc37537k.

Authors

Philip Andrews¹, Christopher M Latham, Marc Magre, Darren Willcox, Simon Woodward

Affiliation

¹ School of Chemistry, The University of Nottingham, University Park, Nottingham, UK.

PMID: 23320257
DOI: 10.1039/c2cc37537k

Abstract

Stabilized AlHCl(2)·(THF)(2) hydroaluminates RC≡CH with exceptional chemo-, regio- and stereoselectivity under efficient ZrCl(2)(η-C(5)Me(5))(2) catalysis (2-5 mol%). The resulting vinyl alanes undergo palladium cross-coupling with a wide range of sp(2) electrophiles (aryl, heteroaryl and vinyl halides/pseudohalides) in good to excellent yields.