Abstract
This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Kidney Injury / drug therapy
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Guanidines / chemistry
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Humans
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Hydroxylamines
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Nitric Oxide / metabolism*
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Prodrugs / chemistry
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Prodrugs / metabolism*
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Prodrugs / therapeutic use
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Vasodilator Agents / chemistry
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Vasodilator Agents / metabolism*
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Vasodilator Agents / therapeutic use
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gamma-Glutamyltransferase / metabolism*
Substances
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Guanidines
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Hydroxylamines
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Prodrugs
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Vasodilator Agents
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Nitric Oxide
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hydroxyguanidine
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gamma-Glutamyltransferase