Synthesis and characterization of novel biologically active platinum(II) and palladium(II) complexes of some beta-carboline alkaloids

J Inorg Biochem. 1990 Jan;38(1):47-56. doi: 10.1016/0162-0134(90)85006-i.

Abstract

The preparation of novel biologically active platinum(II) and palladium(II) complexes of some beta-carboline alkaloids (harmaline, harmalol, harmine, and harmane) is described. These complexes, characterized on the basis of their CHN elemental analysis, infrared, Raman and 1H and 13C nuclear resonance spectral data, were shown to have the empirical formula [M(alkaloid)Cl2], M = Pt, Pd. The antitumor and antiviral activities of some of these complexes have been demonstrated.

MeSH terms

  • Alkaloids* / analysis
  • Alkaloids* / pharmacology
  • Antineoplastic Agents
  • Antiviral Agents
  • Carbolines* / chemical synthesis
  • Harmaline* / analogs & derivatives
  • Harmaline* / analysis
  • Harmaline* / pharmacology
  • Harmine* / analogs & derivatives
  • Harmine* / analysis
  • Harmine* / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Organometallic Compounds* / chemical synthesis
  • Organoplatinum Compounds*
  • Palladium*
  • Spectrophotometry, Infrared
  • Spectrum Analysis, Raman
  • Tumor Cells, Cultured

Substances

  • Alkaloids
  • Antineoplastic Agents
  • Antiviral Agents
  • Carbolines
  • Organometallic Compounds
  • Organoplatinum Compounds
  • harmalol
  • Harmine
  • Palladium
  • harman
  • Harmaline