Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy

Hai Wang; Yan Wu; Ruifang Zhao; Guangjun Nie

doi:10.1002/adma.201204750

Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy

Adv Mater. 2013 Mar 20;25(11):1616-22. doi: 10.1002/adma.201204750. Epub 2013 Jan 22.

Authors

Hai Wang¹, Yan Wu, Ruifang Zhao, Guangjun Nie

Affiliation

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology (NCNST), Zhongguancun, Beijing, P R China.

PMID: 23341059
DOI: 10.1002/adma.201204750

Abstract

The rapid development of nanotechnology holds great promise for revolutionizing the current landscape of tumor drug delivery. However, one of the biggest challenges is developing a simple nanocarrier platform to co-deliver various therapeutic agents. Here, a strategy for fabricating nanocarriers with many desirable features is demonstrated. The resulting nanoparticles achieve both high antitumor efficacy and effective inhibition of tumor metastasis with minimal side effects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Cell Survival / drug effects
Doxorubicin / administration & dosage
Drug Carriers / chemistry*
Fluorescein-5-isothiocyanate / chemistry
Lung Neoplasms / drug therapy
Lung Neoplasms / secondary
Melanoma, Experimental / pathology
Mice
Nanomedicine
Nanoparticles / chemistry*
Nanoparticles / therapeutic use
Nanoparticles / toxicity
Paclitaxel / administration & dosage
Polyethylene Glycols / chemistry
Polyglutamic Acid / analogs & derivatives
Polyglutamic Acid / chemistry

Substances

Antineoplastic Agents
Drug Carriers
methoxypoly(ethylene glycol)-block-poly(glutamic acid)
Polyglutamic Acid
Polyethylene Glycols
Doxorubicin
Fluorescein-5-isothiocyanate
Paclitaxel