Abstract
The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally. However, in both cases this inhibitory effect was transient.
MeSH terms
-
Administration, Oral
-
Animals
-
Antiviral Agents / administration & dosage
-
Antiviral Agents / pharmacology*
-
Antiviral Agents / therapeutic use
-
Arabinofuranosyluracil / administration & dosage
-
Arabinofuranosyluracil / analogs & derivatives*
-
Arabinofuranosyluracil / pharmacology
-
Arabinofuranosyluracil / therapeutic use
-
Chronic Disease
-
Cytarabine / administration & dosage
-
Cytarabine / analogs & derivatives*
-
Cytarabine / pharmacology
-
Hepadnaviridae / drug effects*
-
Hepadnaviridae / physiology
-
Hepatitis, Viral, Animal / drug therapy*
-
Hepatitis, Viral, Animal / microbiology
-
Uridine / analogs & derivatives*
-
Virus Replication / drug effects*
Substances
-
Antiviral Agents
-
Cytarabine
-
Arabinofuranosyluracil
-
fiacitabine
-
2'-fluoro-5-ethylarabinosyluracil
-
clevudine
-
Uridine