The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis

Immunology. 2013 Jun;139(2):161-5. doi: 10.1111/imm.12072.

Abstract

The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation / genetics
  • Cell Differentiation / immunology
  • Epigenesis, Genetic*
  • Hematopoiesis / genetics*
  • Hematopoiesis / immunology
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / immunology
  • Hematopoietic Stem Cells / metabolism
  • Histone Acetyltransferases / genetics*
  • Histone Acetyltransferases / immunology
  • Histone Acetyltransferases / metabolism
  • Humans
  • Immune System / cytology
  • Immune System / immunology
  • Immune System / metabolism
  • Models, Genetic
  • Models, Immunological
  • Trans-Activators*

Substances

  • Trans-Activators
  • Histone Acetyltransferases
  • KAT6A protein, human