Joining of the c-myc gene and a line 1 family member on chromosome 8 in a human primary giant cell carcinoma of the lung

M Iizuka; M Shiraishi; M C Yoshida; K Hayashi; T Sekiya

Joining of the c-myc gene and a line 1 family member on chromosome 8 in a human primary giant cell carcinoma of the lung

Cancer Res. 1990 Jun 1;50(11):3345-50.

Authors

M Iizuka¹, M Shiraishi, M C Yoshida, K Hayashi, T Sekiya

Affiliation

¹ Oncogene Division, National Cancer Center Research Institute, Tokyo, Japan.

PMID: 2334929

Abstract

A rearranged c-myc gene found in a human primary giant cell carcinoma of the lung was analyzed. The rearrangement was found in the region about 6 kilobase pairs upstream of the c-myc gene. The breakpoint was joined to a sequence carrying a Line 1 (L1) family member located on chromosome 8. This in vivo rearrangement of the c-myc gene specific to tumor cells may represent one mechanism of activation of a protooncogene during tumorigenesis or tumor progression in human cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Carcinoma / genetics*
Chromosomes, Human, Pair 8*
DNA Damage*
DNA, Neoplasm / analysis*
Gene Amplification
Gene Rearrangement / genetics*
Humans
Lung Neoplasms / genetics*
Molecular Sequence Data
Oncogenes*

Substances

DNA, Neoplasm