Hyperglycaemia and β-cell antibodies: is it always pre-type 1 diabetes?

Diabetes Res Clin Pract. 2013 Apr;100(1):e20-2. doi: 10.1016/j.diabres.2013.01.003. Epub 2013 Jan 24.

Abstract

We describe 10-year-old girl with mild incidental hyperglycaemia, impaired glucose tolerance and GADA positivity. Family history for mild hyperglycaemia and GADA fluctuation alerted us to a possible MODY diagnosis which was confirmed by detection of GCK mutation c.626C>T; p.T209M. Weak or transient β-cell autoimmunity should not preclude genetic testing for MODY when the clinical features are suggestive.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / blood*
  • Blood Glucose / metabolism
  • Child
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / immunology*
  • Female
  • Follow-Up Studies
  • Genetic Testing
  • Glucokinase / genetics*
  • Glucose Tolerance Test
  • Glycated Hemoglobin / metabolism
  • Humans
  • Hyperglycemia / blood
  • Hyperglycemia / genetics
  • Hyperglycemia / immunology
  • Insulin / blood
  • Insulin-Secreting Cells / immunology*
  • Methionine
  • Point Mutation*
  • Prediabetic State / blood
  • Prediabetic State / genetics
  • Prediabetic State / immunology
  • Threonine

Substances

  • Autoantibodies
  • Blood Glucose
  • Glycated Hemoglobin A
  • Insulin
  • hemoglobin A1c protein, human
  • Threonine
  • Methionine
  • Glucokinase

Supplementary concepts

  • Maturity-Onset Diabetes of the Young, Type 2