Transcatheter aortic valve replacement (TAVR) has emerged as a less invasive therapeutic option for high-risk patients with aortic stenosis (AS) in Europe and US. Data on TAVR are relatively limited in Japan. We report a first TAVR case in Japan of successful TAVR following percutaneous coronary intervention (PCI). A 75-year-old man with stable angina pectoris and severe AS was considered to be at high risk for surgical AVR because of severely calcified ascending aorta. He underwent transfemoral TAVR after undergoing PCI of left circumflex artery. The procedure was successful and the patient was discharged on the 10th postoperative day.