Gold nanotip array for ultrasensitive electrochemical sensing and spectroscopic monitoring

Yueyue Jiang; Fanben Meng; Dianpeng Qi; Pingqiang Cai; Zongyou Yin; Fangwei Shao; Hua Zhang; Freddy Boey; Xiaodong Chen

doi:10.1002/smll.201202620

Gold nanotip array for ultrasensitive electrochemical sensing and spectroscopic monitoring

Small. 2013 Jul 8;9(13):2260-5. doi: 10.1002/smll.201202620. Epub 2013 Jan 30.

Authors

Yueyue Jiang¹, Fanben Meng, Dianpeng Qi, Pingqiang Cai, Zongyou Yin, Fangwei Shao, Hua Zhang, Freddy Boey, Xiaodong Chen

Affiliation

¹ School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.

PMID: 23362212
DOI: 10.1002/smll.201202620

Abstract

A gold nanotip array platform with a combination of ultrasensitive electrochemical sensing and spectroscopic monitoring capability is reported. Adenosine triphosphate is detected down to 1 pM according to the impedance changes in response to aptamer-specific binding. Furthermore, the local molecular information can be monitored at the individual plasmonic nanotips, and hence provide the capability for a better understanding of complex biological processes.

Keywords: adenosine triphosphate; nanotip arrays; raman scattering; redox electrochemistry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphate / analysis
DNA / chemistry
Dimethylpolysiloxanes / chemistry
Electrochemical Techniques / instrumentation*
Gold / chemistry*
Methylene Blue / chemistry
Nanotechnology / instrumentation*
Spectrum Analysis, Raman*

Substances

Dimethylpolysiloxanes
Gold
Adenosine Triphosphate
DNA
Methylene Blue