Does the APC/C Mark MIWI and piRNAs for a final farewell?

Yuliya Sytnikova; Nelson C Lau

doi:10.1016/j.devcel.2013.01.005

Does the APC/C Mark MIWI and piRNAs for a final farewell?

Dev Cell. 2013 Jan 28;24(2):119-20. doi: 10.1016/j.devcel.2013.01.005.

Authors

Yuliya Sytnikova¹, Nelson C Lau

Affiliation

¹ Department of Biology and Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, MA 02454, USA.

Abstract

Recently in Developmental Cell, Zhao et al. (2013) reported a mechanism for the directed turnover of the mouse Piwi protein MIWI during sperm maturation. This study implicates the anaphase-promoting complex as a mediator of MIWI ubiquitination and expands the avenues for regulating small RNA processes.

Publication types

Comment

Grants and funding

R00 HD057298/HD/NICHD NIH HHS/United States