The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer

Miriam Lohr; Karolina Edlund; Johan Botling; Seddik Hammad; Birte Hellwig; Amnah Othman; Anders Berglund; Mats Lambe; Lars Holmberg; Simon Ekman; Michael Bergqvist; Fredrik Pontén; Cristina Cadenas; Rosemarie Marchan; Jan G Hengstler; Jörg Rahnenführer; Patrick Micke

doi:10.1016/j.canlet.2013.01.036

The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer

Cancer Lett. 2013 Jun 10;333(2):222-8. doi: 10.1016/j.canlet.2013.01.036. Epub 2013 Jan 28.

Authors

Miriam Lohr¹, Karolina Edlund, Johan Botling, Seddik Hammad, Birte Hellwig, Amnah Othman, Anders Berglund, Mats Lambe, Lars Holmberg, Simon Ekman, Michael Bergqvist, Fredrik Pontén, Cristina Cadenas, Rosemarie Marchan, Jan G Hengstler, Jörg Rahnenführer, Patrick Micke

Affiliation

¹ Dept. of Statistics, TU Dortmund University, Dortmund, Germany.

PMID: 23370224
DOI: 10.1016/j.canlet.2013.01.036

Abstract

A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray. IGKC protein expression was independently associated with longer survival, with particular impact in the adenocarcinoma subgroup. Moreover, a correlation was seen with CD138+ cells, but not with CD20. CD138 expression revealed a comparable association with survival. In conclusion, IGKC expression in stroma-infiltrating plasma cells is a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Antigens, CD20 / metabolism
B-Lymphocytes / immunology
B-Lymphocytes / pathology
Carcinoma, Non-Small-Cell Lung / immunology*
Carcinoma, Non-Small-Cell Lung / mortality*
Carcinoma, Non-Small-Cell Lung / pathology
Female
Gene Expression Regulation, Neoplastic
Humans
Immunity, Humoral
Immunoglobulin kappa-Chains / genetics*
Immunoglobulin kappa-Chains / metabolism
Lung Neoplasms / immunology*
Lung Neoplasms / mortality*
Lung Neoplasms / pathology
Lymphocytes, Tumor-Infiltrating
Male
Middle Aged
Plasma Cells / immunology
Plasma Cells / metabolism
Plasma Cells / pathology
Prognosis
Stromal Cells / immunology
Syndecan-1 / metabolism
Tissue Array Analysis

Substances

Antigens, CD20
Immunoglobulin kappa-Chains
SDC1 protein, human
Syndecan-1