Case studies in the management of refractory bleeding in patients with haemophilia A and inhibitors

Haemophilia. 2013 May;19(3):e151-66. doi: 10.1111/hae.12095. Epub 2013 Feb 4.

Abstract

In haemophilia patients with well-established high-titer inhibitors, even seemingly minor acute bleeding episodes or surgical procedures may become refractory to treatment and transform into limb- or life-threatening situations. In the absence of evidence-based treatment guidelines, this article presents 10 cases of difficult to control acute and surgical bleeding and offers consensus opinions regarding their management from a panel of experienced haemophilia treaters.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arthroplasty, Replacement, Knee
  • Blood Coagulation Factor Inhibitors / blood*
  • Child, Preschool
  • Factor VIII / antagonists & inhibitors*
  • Factor VIII / metabolism
  • Factor VIIa / therapeutic use
  • Hemophilia A / surgery
  • Hemophilia A / therapy*
  • Hemorrhage*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Recombinant Proteins / therapeutic use

Substances

  • Blood Coagulation Factor Inhibitors
  • Immunosuppressive Agents
  • Recombinant Proteins
  • Factor VIII
  • recombinant FVIIa
  • Factor VIIa