Abstract
The synthesis of 5H-pyrrolo[1,2-b][1,2,5]benzotriazepine derivatives related to imipramine and aptazepine antidepressant agents is reported. Pharmacological screening on new tricyclic derivatives showed that in some cases antidepressant effects at equimolecular dose with imipramine are associated with sedative-muscle relaxant activities and antinociception.
MeSH terms
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Animals
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Anticonvulsants
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Antidepressive Agents / chemical synthesis*
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Benzazepines / chemical synthesis*
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Benzazepines / pharmacology
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Chemical Phenomena
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Chemistry
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Exploratory Behavior / drug effects
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Female
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Male
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Mice
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Motor Activity / drug effects
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Muscle Relaxants, Central
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Pain / drug therapy
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Postural Balance / drug effects
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Psychotropic Drugs / chemical synthesis*
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology
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Sensory Thresholds / drug effects
Substances
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Anticonvulsants
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Antidepressive Agents
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Benzazepines
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Muscle Relaxants, Central
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Psychotropic Drugs
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Pyrroles