Montmorillonite K-10 catalyzed green synthesis of 2,6-unsubstituted dihydropyridines as potential inhibitors of PDE4

Eur J Med Chem. 2013 Apr:62:395-404. doi: 10.1016/j.ejmech.2012.12.052. Epub 2013 Jan 17.

Abstract

Montmorillonite K-10 mediated MCR of anilines, arylaldehydes and ethyl-3,3-diethoxypropionate in water afforded 2,6-unsubstituted dihydropyridines depending on the nature of anilines employed. A variety of dihydropyridines were prepared by using this green methodology in good yields and montmorillonite K-10 was found to be an inexpensive and reusable catalyst. The structure elaboration of a representative compound was carried out under Heck conditions. Some of the compounds synthesized showed significant inhibition of PDE4B when tested in vitro. Docking studies indicated that one of the ester moieties of these compounds played a key role in their interactions with the PDE4B protein.

MeSH terms

  • Bentonite / chemistry*
  • Catalysis
  • Cyclic Nucleotide Phosphodiesterases, Type 4 / metabolism*
  • Dihydropyridines / chemical synthesis
  • Dihydropyridines / chemistry
  • Dihydropyridines / pharmacology*
  • Dose-Response Relationship, Drug
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Phosphodiesterase 4 Inhibitors / chemical synthesis
  • Phosphodiesterase 4 Inhibitors / chemistry
  • Phosphodiesterase 4 Inhibitors / pharmacology*
  • Structure-Activity Relationship

Substances

  • Dihydropyridines
  • Phosphodiesterase 4 Inhibitors
  • montmorillonite K-10
  • Bentonite
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • PDE4B protein, human