The effect of protein composition on hydration dynamics

Phys Chem Chem Phys. 2013 Mar 14;15(10):3570-6. doi: 10.1039/c3cp44582h. Epub 2013 Feb 4.

Abstract

Water dynamics at the surface of two homologous proteins with different thermal resistances is found to be unaffected by the different underlying amino-acid compositions, and when proteins are folded it responds similarly to temperature variations. Upon unfolding the water dynamics slowdown with respect to bulk decreases by a factor of two. Our findings are explained by the dominant topological perturbation induced by the protein on the water hydrogen bond dynamics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Computer Simulation*
  • Hydrogen Bonding
  • Models, Molecular
  • Protein Folding
  • Proteins / chemistry*
  • Water / chemistry*

Substances

  • Amino Acids
  • Proteins
  • Water