Reversion of naturally occurring high-level resistance mutations to NS3 protease inhibitors in two treatment-naive individuals infected with hepatitis C virus

J Antimicrob Chemother. 2013 Jun;68(6):1448-50. doi: 10.1093/jac/dkt019. Epub 2013 Feb 6.
No abstract available

Keywords: HCV; HIV; natural strains.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution / genetics
  • Antiviral Agents / pharmacology*
  • CD4 Lymphocyte Count
  • Drug Resistance, Viral / genetics*
  • HIV Infections / complications
  • HIV Protease Inhibitors / pharmacology*
  • HIV Protease Inhibitors / therapeutic use
  • Hepacivirus / drug effects*
  • Hepacivirus / genetics*
  • Hepatitis C / drug therapy*
  • Hepatitis C / virology*
  • Humans
  • Mutation / genetics*
  • RNA, Viral / blood
  • Viral Nonstructural Proteins / genetics*

Substances

  • Antiviral Agents
  • HIV Protease Inhibitors
  • NS3 protein, hepatitis C virus
  • RNA, Viral
  • Viral Nonstructural Proteins