A spike of electrodiffusion reaches metabotropic receptors

Eric Schwartz; Boris Barbour

doi:10.1016/j.neuron.2013.01.024

A spike of electrodiffusion reaches metabotropic receptors

Neuron. 2013 Feb 6;77(3):381-4. doi: 10.1016/j.neuron.2013.01.024.

Authors

Eric Schwartz¹, Boris Barbour

Affiliation

¹ Institut de Biologie de l'ENS, IBENS, F-75005 Paris, France.

PMID: 23395368
DOI: 10.1016/j.neuron.2013.01.024

Abstract

Flow of current in the synaptic cleft can influence diffusion of charged transmitters, such as glutamate. In this issue of Neuron, Sylantyev et al. (2013) demonstrate how this can modulate synaptic NMDA receptor-mediated responses via a surprising mechanism-perisynaptic metabotropic glutamate receptors.

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