A "complex" issue: deciphering the role of variant PRC1 in ESCs

Siobhán A Turner; Adrian P Bracken

doi:10.1016/j.stem.2013.01.014

A "complex" issue: deciphering the role of variant PRC1 in ESCs

Cell Stem Cell. 2013 Feb 7;12(2):145-6. doi: 10.1016/j.stem.2013.01.014.

Authors

Siobhán A Turner¹, Adrian P Bracken

Affiliation

¹ The Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.

PMID: 23395440
DOI: 10.1016/j.stem.2013.01.014

Abstract

Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et al. (2012a) and Wu et al. (2013) define functionally distinct roles for canonical and noncanonical PRC1 in ESCs.

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