Immune- and wound-dependent differential gene expression in an ancient insect

Dev Comp Immunol. 2013 Jul-Aug;40(3-4):320-4. doi: 10.1016/j.dci.2013.01.012. Epub 2013 Feb 8.

Abstract

Two of the main functions of the immune system are to control infections and to contribute to wound closure. Here we present the results of an RNAseq study of immune- and wound-response gene expression in the damselfly Coenagrion puella, a representative of the odonates, the oldest taxon of winged insects. De novo assembly of RNAseq data revealed a rich repertoire of canonical immune pathways, as known from model insects, including recognition, transduction and effector gene expression. A shared set of immune and wound repair genes were differentially expressed in both wounded and immune-challenged larvae. Moreover 3-fold more immune genes were induced only in the immune-challenged treatment. This is consistent with the notion that the immune-system reads a balance of signals related to wounding and infection and that the response is tailored accordingly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Escherichia coli / immunology
  • Gene Expression Regulation / immunology*
  • Host-Pathogen Interactions
  • Immune System
  • Immunity, Innate / genetics
  • Insect Proteins / genetics
  • Insect Proteins / metabolism*
  • Larva / immunology
  • Larva / metabolism
  • Larva / microbiology
  • Odonata / immunology
  • Odonata / metabolism*
  • Odonata / microbiology
  • Staphylococcus aureus / immunology
  • Transcriptome
  • Wound Healing / genetics

Substances

  • Insect Proteins