Abstract
Maleimide-functionalised Pt(IV) complexes with highly selective binding properties to thiol groups were synthesised as precursors for binding of thiol-containing tumour-targeting molecules like human serum albumin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / pathology
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Drug Delivery Systems*
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Humans
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Maleimides / chemistry*
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Mice
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Mice, Inbred BALB C
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Models, Molecular
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Molecular Structure
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / chemistry
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Organoplatinum Compounds / pharmacology*
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Prodrugs / chemical synthesis
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Prodrugs / chemistry
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Prodrugs / pharmacology*
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Serum Albumin / analysis*
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Structure-Activity Relationship
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Sulfhydryl Compounds / chemistry
Substances
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Antineoplastic Agents
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Maleimides
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Organoplatinum Compounds
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Prodrugs
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Serum Albumin
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Sulfhydryl Compounds
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maleimide