Abstract
Psoriasis is an immune-mediated, chronic, inflammatory disease that affects the skin and joints. Because of its high incidence and of its clinical symptoms it has a very strong social impact. In a genetically predisposed individual, the maintenance of the skin barrier integrity is strongly compromised in response to either environmental or self-antigenic insults. A persistent dysregulation of the skin immune system causes the typical evolutive skin lesions of psoriasis and recurrence of the disease. The most efficient laboratory approach consists of a well-defined evaluation of immune response in order to help diagnosis, to monitor evolution, and to evaluate the effects of individualized therapeutic treatments.
MeSH terms
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Antibodies, Monoclonal / therapeutic use*
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Biomarkers / analysis
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Disease Progression
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Forkhead Transcription Factors / genetics
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Forkhead Transcription Factors / immunology
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Gene Expression
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HLA-C Antigens / genetics
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HLA-C Antigens / immunology
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Humans
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Immune System / drug effects*
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Interleukin-17 / antagonists & inhibitors
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Interleukin-17 / genetics
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Interleukin-17 / immunology
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Interleukin-23 / antagonists & inhibitors
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Interleukin-23 / genetics
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Interleukin-23 / immunology
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Polymerase Chain Reaction
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Protein Array Analysis
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Psoriasis / diagnosis*
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Psoriasis / immunology
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Psoriasis / pathology
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Psoriasis / therapy*
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Skin / drug effects
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Skin / immunology*
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Skin / pathology
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T-Lymphocytes, Regulatory / immunology
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T-Lymphocytes, Regulatory / pathology
Substances
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Antibodies, Monoclonal
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Biomarkers
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FOXP3 protein, human
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Forkhead Transcription Factors
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HLA-C Antigens
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HLA-C*06:02 antigen
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Interleukin-17
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Interleukin-23