Abstract
HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3⁺ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adaptive Immunity
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Adolescent
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Adult
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Antigens, CD1d / biosynthesis
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CD4 Antigens / metabolism
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Female
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Forkhead Transcription Factors / metabolism
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HIV Infections / immunology*
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HIV Infections / virology*
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HIV-1 / classification*
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HIV-1 / immunology*
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Humans
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Interleukin-2 / biosynthesis
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Lymphocyte Activation
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Male
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Middle Aged
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Natural Killer T-Cells / immunology*
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T-Lymphocytes, Regulatory / immunology*
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Young Adult
Substances
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Antigens, CD1d
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CD1D protein, human
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CD4 Antigens
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FOXP3 protein, human
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Forkhead Transcription Factors
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Interleukin-2