Synthesis and characterization of bactericidal silver nanoparticles using cultural filtrate of simulated microgravity grown Klebsiella pneumoniae

Enzyme Microb Technol. 2013 Mar 5;52(3):151-6. doi: 10.1016/j.enzmictec.2012.12.006. Epub 2012 Dec 27.

Abstract

Silver nanoparticles were synthesized by biological method using cultural filtrate of Klebsiella pneumoniae cultured under simulated microgravity and silver nitrate solution as precursor. The nanoparticles exhibited typical plasmon absorption maximum of silver nanoparticles between 405 and 407 nm. Spherical silver nanoparticles were found to have size between 15 and 37 nm by TEM analysis. XRD pattern corresponding to planes (111), (200), (220) (311) revealed the crystalline nature of the biosynthesized silver nanoparticles. FTIR spectrum proposed stabilization of silver nanoparticles by the protein molecules present in the cultural filtrate. The silver nanoparticles exhibited high bactericidal activity against Salmonella enterica, Escherichia coli and moderate bactericidal activity against Streptococcus pyogenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / metabolism*
  • Colorimetry
  • Culture Media, Conditioned
  • Escherichia coli / drug effects
  • Filtration
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / growth & development
  • Microbial Sensitivity Tests
  • Microscopy, Electron
  • Nanoparticles*
  • Nitrate Reductase / metabolism*
  • Oxidation-Reduction
  • Particle Size
  • Salmonella enterica / drug effects
  • Silver / pharmacology*
  • Silver Nitrate / metabolism
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared
  • Streptococcus pyogenes / drug effects
  • Surface Properties
  • Weightlessness Simulation

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Culture Media, Conditioned
  • Silver
  • Silver Nitrate
  • Nitrate Reductase