Chimeric Ply187 endolysin kills Staphylococcus aureus more effectively than the parental enzyme

FEMS Microbiol Lett. 2013 May;342(1):30-6. doi: 10.1111/1574-6968.12104. Epub 2013 Mar 15.

Abstract

Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall-binding domain is a potent agent against Staphylococcus aureus in four functional assays.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Endopeptidases / genetics
  • Endopeptidases / metabolism*
  • Microbial Viability / drug effects*
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / physiology*

Substances

  • Recombinant Fusion Proteins
  • Endopeptidases
  • endolysin