Abstract
Two new small compounds, which undergo fluoride-mediated self rearrangement, produce active DNA alkylating agent nitrogen mustard leading to DNA damage and finally cell death, providing potential antitumor prodrugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Chromatography, High Pressure Liquid
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Cross-Linking Reagents / pharmacology*
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DNA / drug effects*
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Electrophoresis, Gel, Two-Dimensional
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Fluorides / pharmacology*
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HeLa Cells
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Humans
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Molecular Structure
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Prodrugs / chemistry
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Prodrugs / pharmacology*
Substances
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Antineoplastic Agents
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Cross-Linking Reagents
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Prodrugs
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DNA
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Fluorides