Abstract
A small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymers, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu), was developed in order to provide a tumor acidosis-triggered delivery system with low cytotoxicity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology*
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Drug Delivery Systems*
-
Drug Screening Assays, Antitumor
-
Electrolytes / chemistry
-
Electrolytes / pharmacology
-
Glutamic Acid / chemistry*
-
Histidine / chemistry*
-
Humans
-
Hydrogen-Ion Concentration
-
Models, Molecular
-
Molecular Structure
-
Polyethylene Glycols / chemistry
-
Polyethylene Glycols / pharmacology*
-
Polyethyleneimine / chemistry
-
Polyethyleneimine / pharmacology*
-
RNA, Small Interfering / chemistry
-
RNA, Small Interfering / pharmacology*
-
Structure-Activity Relationship
Substances
-
Antineoplastic Agents
-
Electrolytes
-
RNA, Small Interfering
-
Glutamic Acid
-
Polyethylene Glycols
-
Histidine
-
Polyethyleneimine