Reducing infectivity of HIV upon exposure to surfaces coated with N,N-dodecyl, methyl-polyethylenimine

Biotechnol Bioeng. 2013 Jul;110(7):2058-62. doi: 10.1002/bit.24867. Epub 2013 Apr 7.

Abstract

The infectivity of high-titer, cell-free HIV in culture media and human milk is rapidly reduced upon exposure to polyethylene slides painted with the linear hydrophobic polycation N,N-dodecyl,methyl-polyethylenimine (DMPEI). Accompanying viral p24 protein and free viral RNA analysis of solutions exposed to DMPEI-coated surfaces suggests that virion attachment to the polycationic surface and its subsequent inactivation are the likely mechanism of this phenomenon.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Disinfectants / pharmacology*
  • Environmental Microbiology*
  • Equipment and Supplies / virology*
  • HIV / drug effects*
  • Humans
  • Microbial Viability / drug effects
  • Polyethyleneimine / analogs & derivatives*
  • Polyethyleneimine / pharmacology
  • Viral Load

Substances

  • Disinfectants
  • N,N-dodecyl,methyl-polyethylenimine
  • Polyethyleneimine