Abstract
γδ T lymphocytes are major providers of the pro-inflammatory cytokines interferon-γ (IFN-γ) and interleukin-17 (IL-17) at early stages of (auto)immune responses. We and others have recently described the phenotype and differentiation requirements of two distinct murine γδ T cell subsets producing either IFN-γ or IL-17. Here we summarize our current understanding of the molecular mechanisms that control γδ T cell differentiation, which is programmed in the thymus, and peripheral activation upon infection. We focus on the costimulatory receptors CD27 and CD28, which play independent and non-redundant roles in the physiology of γδ T cells in mice and in humans.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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CD28 Antigens / genetics
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CD28 Antigens / immunology*
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Cell Differentiation / immunology
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Gene Expression
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Humans
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Immunity, Innate
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Interferon-gamma / biosynthesis
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Interferon-gamma / immunology
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Interleukin-17 / biosynthesis
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Interleukin-17 / immunology
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Lymphocyte Activation / immunology*
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Mice
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Receptors, Antigen, T-Cell, gamma-delta / immunology*
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / immunology*
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Thymus Gland / cytology
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Thymus Gland / immunology
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Tumor Necrosis Factor Receptor Superfamily, Member 7 / genetics
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Tumor Necrosis Factor Receptor Superfamily, Member 7 / immunology*
Substances
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CD28 Antigens
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Interleukin-17
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Receptors, Antigen, T-Cell, gamma-delta
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Tumor Necrosis Factor Receptor Superfamily, Member 7
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Interferon-gamma