Abstract
Strontium ranelate (SR) effect on the functional parameters of human blood mononuclear leukocytes culture has been investigated. SR in concentrations of 2.9, 29, and 290 mg/ml produces a dose-dependent decrease in the activity of alkaline phosphatase and the content of calcium and potassium ions in supernatants. In concentrations of 2.9 and 29 mg/ml, SR decreases, while in a concentration of 290 mg/ml it increases the intercellular phosphate ion content. Fibroblast- and osteoblast-like cells, which are capable of regulating mineral compound of intercellular liquid, are SR cellular targets in human blood mononuclear leukocytes culture.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alkaline Phosphatase / metabolism
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Bone Density Conservation Agents / pharmacology*
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Calcium / metabolism
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Cells, Cultured
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Dose-Response Relationship, Drug
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Humans
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Ion Transport / drug effects
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Leukocytes, Mononuclear / cytology
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Leukocytes, Mononuclear / drug effects*
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Leukocytes, Mononuclear / metabolism
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Organometallic Compounds / pharmacology*
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Phosphates / metabolism
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Potassium / metabolism
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Thiophenes / pharmacology*
Substances
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Bone Density Conservation Agents
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Organometallic Compounds
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Phosphates
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Thiophenes
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strontium ranelate
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Alkaline Phosphatase
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Potassium
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Calcium