Diagnostic and therapeutic management of eosinophilic oesophagitis in children and adults: results from a Spanish registry of clinical practice

Dig Liver Dis. 2013 Jul;45(7):562-8. doi: 10.1016/j.dld.2013.01.013. Epub 2013 Feb 23.

Abstract

Background: Eosinophilic oesophagitis has emerged as a common cause of oesophageal symptoms.

Aims: To document practice variation in care provided to eosinophilic oesophagitis patients in Spain and to assess adherence to available guidelines.

Methods: A prospective survey-based registry including data from all patients receiving care from gastroenterologists and allergists throughout Spain was developed.

Results: Data from 705 patients (82% adults, male:female ratio 4.1:1) were collected from 26 Spanish hospitals. 42.7% received care in teaching hospitals. Adults presented dysphagia and food impaction more frequently; vomiting and weight loss predominated in children (p < 0.01). A mean diagnostic delay of 54.7 and 28.04 months was documented for adults and children, respectively. Normal endoscopic exams were reported in 27.6% and directly related to the experience in managing the disease (p < 0.05). Paediatric patients, non-teaching hospitals and greater experience in managing eosinophilic oesophagitis were associated with increased frequency in eosinophil count reports and with taking gastric and duodenal biopsies (p < 0.001). Initial therapy consisted of topical steroids (61.7% of patients), proton pump inhibitors (52.4%), dietary modifications (51.26%) and endoscopic dilation (7.2%). Referrals to allergy units occurred more frequently in teaching hospitals (p = 0.003) where food restrictions generally followed allergy test results (p < 0.001).

Conclusions: Availability of facilities and the physician's experience constituted the most important factors in explaining differences in patient management.

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Aged
  • Aged, 80 and over
  • Allergy and Immunology / standards
  • Biopsy
  • Child
  • Child, Preschool
  • Diet Therapy
  • Dilatation
  • Eosinophilic Esophagitis / diagnosis*
  • Eosinophilic Esophagitis / therapy
  • Esophageal pH Monitoring
  • Esophagoscopy
  • Female
  • Gastroenterology / standards
  • Guideline Adherence / statistics & numerical data*
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Practice Guidelines as Topic
  • Practice Patterns, Physicians' / statistics & numerical data*
  • Prospective Studies
  • Proton Pump Inhibitors / therapeutic use
  • Registries*
  • Spain
  • Young Adult

Substances

  • Adrenal Cortex Hormones
  • Proton Pump Inhibitors