Abstract
We investigate the 'marker-of-self' functionalization of nanoparticles through coating of natural RBC membranes. The membrane translocation approach is shown to be highly efficient and bestows nanoparticles with correctly oriented and functional immunomodulatory proteins such as CD47 at equivalent density to natural RBCs.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Biomarkers / analysis*
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Biomedical Engineering / methods
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CD47 Antigen / analysis
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CD47 Antigen / metabolism
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Coated Materials, Biocompatible / chemical synthesis
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Coated Materials, Biocompatible / chemistry*
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Erythrocyte Membrane / chemistry
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Erythrocyte Membrane / metabolism*
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Erythrocyte Membrane / physiology
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Hydrogen Bonding
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Hydrophobic and Hydrophilic Interactions
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Lactic Acid / chemistry
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Macrophages / metabolism
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Mice
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Nanoparticles / chemistry*
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Polyglycolic Acid / chemistry
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Polylactic Acid-Polyglycolic Acid Copolymer
Substances
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Biomarkers
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CD47 Antigen
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Cd47 protein, mouse
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Coated Materials, Biocompatible
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid