[Lymphatics in non-tumoral pulmonary diseases. Review]

Rev Pneumol Clin. 2013 Jun;69(3):170-4. doi: 10.1016/j.pneumo.2012.12.008. Epub 2013 Mar 6.
[Article in French]

Abstract

Whereas lymphatics in pulmonary non-tumoral diseases have been less studied than blood microcirculation, they clearly play a significant role. This review is a short update on lymphatics in various non-tumoral pulmonary diseases, from asthma to interstitial pneumonitis, excluding lymphangioleiomyomatosis. A lymphatic remodelling has been evidenced in asthma as well as in acute or chronic (UIP as NSIP) interstitial lung diseases. Such a remodelling can be explained as a side effect of local changes in fluidics but could also be an active player in the fibrosing process. Moreover the association of juxta-alveloar lymphatics and granulomas provides new insights in the emergence of these lesions in pulmonary sarcoidosis.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Humans
  • Lung Diseases / etiology
  • Lung Diseases / immunology
  • Lung Diseases / physiopathology*
  • Lung Diseases, Interstitial / pathology
  • Lung Diseases, Interstitial / physiopathology
  • Lymphatic System / pathology
  • Lymphatic System / physiopathology
  • Lymphatic Vessels / pathology
  • Lymphatic Vessels / physiopathology*
  • Pulmonary Edema / pathology
  • Pulmonary Edema / physiopathology
  • Pulmonary Emphysema / pathology
  • Pulmonary Emphysema / physiopathology