[Characterization of influenza virus reassortants based on new donor strain A/HK/1/68/162/35(H3N2)]

Vopr Virusol. 2012 Nov-Dec;57(6):42-6.
[Article in Russian]

Abstract

Influenza reassortant viruses A/SPb/HK/09(H1N1), A/Astana/HK/2009 (H5N1), A/Otar/HK/2010(H3N8), and A/Perth/ HK/2011(H3N2), carrying surface antigens of different subtypes, were constructed on the basis of new potential unified donor strain A/HK/1/68/162/35(H3N2). The virulence and reproduction activity of the obtained reassortants were tested. The safety of the candidate live and inactivated influenza vaccines produced from the reassortant viruses was demonstrated. The study demonstrates that A/HK/1/68/162/35 can be used as a unified donor for attenuated and high-yield vaccine reassortants.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Humans
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / immunology
  • Influenza A Virus, H1N1 Subtype / pathogenicity
  • Influenza A Virus, H3N2 Subtype / genetics
  • Influenza A Virus, H3N2 Subtype / immunology
  • Influenza A Virus, H3N2 Subtype / pathogenicity
  • Influenza A Virus, H3N8 Subtype / genetics
  • Influenza A Virus, H3N8 Subtype / immunology
  • Influenza A Virus, H3N8 Subtype / pathogenicity
  • Influenza A Virus, H5N1 Subtype / genetics
  • Influenza A Virus, H5N1 Subtype / immunology
  • Influenza A Virus, H5N1 Subtype / pathogenicity
  • Influenza Vaccines* / genetics
  • Influenza, Human* / genetics
  • Influenza, Human* / immunology
  • Influenza, Human* / prevention & control
  • Influenza, Human* / virology
  • Mice
  • Vaccines, Attenuated* / genetics
  • Vaccines, Attenuated* / immunology
  • Vaccines, Inactivated* / genetics
  • Vaccines, Inactivated* / immunology
  • Virus Replication / genetics

Substances

  • Influenza Vaccines
  • Vaccines, Attenuated
  • Vaccines, Inactivated