A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect

Linda F Thompson; Hiroki Tsukamoto; Petya Chernogorova; Robert Zeiser

doi:10.4161/onci.22107

A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect

Oncoimmunology. 2013 Jan 1;2(1):e22107. doi: 10.4161/onci.22107.

Authors

Linda F Thompson¹, Hiroki Tsukamoto, Petya Chernogorova, Robert Zeiser

Affiliation

¹ Oklahoma Medical Research Foundation; Oklahoma City, OK USA.

Abstract

The utility of allogeneic stem cell transplantation for treating hematologic malignancies is enhanced by the graft vs. tumor (GvT) effect, but limited by graft vs. host disease (GvHD). Studies involving the inhibition of CD73 by genetic or pharmacologic means suggest that the levels of CD73-generated adenosine may be manipulated to control GvHD, while maintaining the GvT effect.

Keywords: CD73; adenosine receptor; graft vs. host disease; graft vs. tumor effect.