Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF

Neurology. 2013 Apr 2;80(14):1349-50. doi: 10.1212/WNL.0b013e31828ab325. Epub 2013 Mar 13.

Abstract

A 35-year-old man developed progressive memory problems and personality changes over the course of 6 months. This amnesia culminated in overt functional impairment as he began getting lost in familiar places and paid his rent multiple times in one day. He then displayed increased aggression and was admitted to hospital after assaulting a family member.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies / cerebrospinal fluid*
  • Blood Sedimentation
  • Cranial Nerve Diseases / cerebrospinal fluid*
  • Cranial Nerve Diseases / complications
  • Humans
  • Male
  • Memory Disorders / cerebrospinal fluid*
  • Memory Disorders / complications
  • Personality Disorders / cerebrospinal fluid*
  • Personality Disorders / complications
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate / immunology*

Substances

  • Antibodies
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate