Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells

Development. 2013 Apr;140(8):1655-64. doi: 10.1242/dev.093005. Epub 2013 Mar 13.

Abstract

The mammalian hair follicle relies on adult resident stem cells and their progeny to fuel and maintain hair growth throughout the life of an organism. The cyclical and initially synchronous nature of hair growth makes the hair follicle an ideal system with which to define homeostatic mechanisms of an adult stem cell population. Recently, we demonstrated that Hopx is a specific marker of intestinal stem cells. Here, we show that Hopx specifically labels long-lived hair follicle stem cells residing in the telogen basal bulge. Hopx(+) cells contribute to all lineages of the mature hair follicle and to the interfollicular epidermis upon epidermal wounding. Unexpectedly, our analysis identifies a previously unappreciated progenitor population that resides in the lower hair bulb of anagen-phase follicles and expresses Hopx. These cells co-express Lgr5, do not express Shh and escape catagen-induced apoptosis. They ultimately differentiate into the cytokeratin 6-positive (K6) inner bulge cells in telogen, which regulate the quiescence of adjacent hair follicle stem cells. Although previous studies have suggested that K6(+) cells arise from Lgr5-expressing lower outer root sheath cells in anagen, our studies indicate an alternative origin, and a novel role for Hopx-expressing lower hair bulb progenitor cells in contributing to stem cell homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bromodeoxyuridine
  • Cell Differentiation / physiology*
  • Cell Lineage / physiology
  • Epidermal Cells*
  • Flow Cytometry
  • Hair / growth & development*
  • Hair Follicle / cytology*
  • Homeodomain Proteins / metabolism*
  • In Situ Nick-End Labeling
  • Keratin-6 / metabolism*
  • Keratinocytes / metabolism
  • Keratinocytes / physiology
  • Mice
  • Mice, Transgenic
  • Multipotent Stem Cells / metabolism*
  • Tamoxifen
  • beta-Galactosidase

Substances

  • Hod protein, mouse
  • Homeodomain Proteins
  • Keratin-6
  • Tamoxifen
  • beta-Galactosidase
  • Bromodeoxyuridine