Oxime cross-linked injectable hydrogels for catheter delivery

Adv Mater. 2013 Jun 4;25(21):2937-42. doi: 10.1002/adma.201205234. Epub 2013 Mar 12.

Abstract

Catheter delivery of therapeutic materials is important for developing minimally invasive treatment approaches. However, the majority of injectable materials gel rapidly upon mixing and/or heating to body temperature. The application of an oxime cross-linked hydrogel system is demonstrated. The system has a broad range of tunable gelation rates, is capable of injection through a catheter, and exhibits rapid gelation upon injection into tissue.

Keywords: catheters; injectable hydrogels; oxime cross-linking.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Catheters*
  • Hydrogels / chemistry*
  • Injections
  • Oximes / chemistry*
  • Polyethylene Glycols / chemistry

Substances

  • Biocompatible Materials
  • Hydrogels
  • Oximes
  • Polyethylene Glycols