Hydrogen-bonding effects on the reactivity of [X-Fe(III)-O-Fe(IV)═O] (X = OH, F) complexes toward C-H bond cleavage

Inorg Chem. 2013 Apr 1;52(7):3976-84. doi: 10.1021/ic3027896. Epub 2013 Mar 15.

Abstract

Complexes 1-OH and 1-F are related complexes that share similar [X-Fe(III)-O-Fe(IV)═O](3+) core structures with a total spin S of ½, which arises from antiferromagnetic coupling of an S = 5/2 Fe(III)-X site and an S = 2 Fe(IV)═O site. EXAFS analysis shows that 1-F has a nearly linear Fe(III)-O-Fe(IV) core compared to that of 1-OH, which has an Fe-O-Fe angle of ~130° due to the presence of a hydrogen bond between the hydroxo and oxo groups. Both complexes are at least 1000-fold more reactive at C-H bond cleavage than 2, a related complex with a [OH-Fe(IV)-O-Fe(IV)═O](4+) core having individual S = 1 Fe(IV) units. Interestingly, 1-F is 10-fold more reactive than 1-OH. This raises an interesting question about what gives rise to the reactivity difference. DFT calculations comparing 1-OH and 1-F strongly suggest that the H-bond in 1-OH does not significantly change the electrophilicity of the reactive Fe(IV)═O unit and that the lower reactivity of 1-OH arises from the additional activation barrier required to break its H-bond in the course of H-atom transfer by the oxoiron(IV) moiety.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Coordination Complexes / chemistry*
  • Ferric Compounds / chemistry*
  • Hydrogen / chemistry*
  • Hydrogen Bonding
  • Kinetics
  • Models, Molecular
  • Molecular Mimicry
  • Nonheme Iron Proteins / chemistry
  • Oxidation-Reduction
  • Oxygen / chemistry*

Substances

  • Coordination Complexes
  • Ferric Compounds
  • Nonheme Iron Proteins
  • Hydrogen
  • Oxygen