Spinning the web of cell fate

Cell. 2013 Mar 14;152(6):1213-7. doi: 10.1016/j.cell.2013.02.052.

Abstract

Spatiotemporal changes in nuclear lamina composition underlie cell-type-specific chromatin organization and cell fate, suggesting that the lamina forms a dynamic framework critical for genome function, cellular identity, and developmental potential.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cell Lineage*
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism
  • Humans
  • Lamins / metabolism
  • Nuclear Lamina / metabolism*
  • Stem Cells / metabolism

Substances

  • Lamins