Abstract
Increasing evidence suggests that a link exists between hepatitis B virus (HBV) serum markers and pancreatic cancer (PC). In this study, HBsAg and HBcAg were expressed in 21.0% (34/162) of PC and 29.0% (47/162) of non-tumor pancreatic tissues, and they were significantly associated with chronic pancreatitis (P=0.000). The HBV S, C and X genes were identified in 20% (6/30) of PC and 26.9% (7/26) of non-tumor tissues by PCR. A serological survey revealed that the prevalence of HBV DNA and anti-HBc was significantly increased in PC patients compared with healthy controls. Our data suggest that HBV infection in the pancreas may play an etiologic role in PC.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers / blood
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DNA, Viral / isolation & purification*
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Female
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Hepatitis B / genetics
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Hepatitis B / immunology
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Hepatitis B / virology
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Hepatitis B Antibodies
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Hepatitis B Core Antigens* / blood
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Hepatitis B Core Antigens* / genetics
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Hepatitis B Core Antigens* / immunology
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Hepatitis B Surface Antigens* / blood
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Hepatitis B Surface Antigens* / genetics
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Hepatitis B Surface Antigens* / immunology
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Hepatitis B e Antigens / blood
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Hepatitis B e Antigens / immunology
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Hepatitis B virus* / genetics
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Hepatitis B virus* / immunology
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Hepatitis B virus* / isolation & purification
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Humans
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Male
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Middle Aged
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Pancreas / virology
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Pancreatic Neoplasms / virology*
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Pancreatitis, Chronic / virology
Substances
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Biomarkers
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DNA, Viral
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Hepatitis B Antibodies
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Hepatitis B Core Antigens
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Hepatitis B Surface Antigens
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Hepatitis B e Antigens