Lithium-selective phosphine oxide-based ditopic receptors show enhanced halide binding upon alkali metal ion coordination

Chem Sci. 2013 Jan 1;4(2):585-590. doi: 10.1039/C2SC21501B. Epub 2012 Oct 30.

Abstract

Previous work on a ditopic receptor based on a tripodal phosphine oxide core demonstrated preferential enhancement of bromide binding over chloride or iodide in the presence of lithium cation. Current studies on an elongated receptor provide evidence that preferential bromide binding enhancement in the presence of lithium cation is common to this receptor class in general, and that lengthening of the receptor results in an overall increase in halide association. Furthermore, the extended receptor shows a strong preference for Li+ binding in solution.