Interactions of a periplasmic binding protein with a tetradentate siderophore mimic

Angew Chem Int Ed Engl. 2013 Apr 22;52(17):4595-8. doi: 10.1002/anie.201300751. Epub 2013 Mar 19.

Abstract

Iron-bound structure: The ferric complex of a tetradentate siderophore mimic was synthesized and co-crystallized with the periplasmic binding protein CeuE of Campylobacter jejuni. In addition to electrostatic and hydrogen-bonding interactions between the binding pocket and the substrate, the structure showed direct coordination of two amino acid side chains to the Fe(III) center (orange, see figure).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Biomimetic Materials / chemistry
  • Coordination Complexes / chemistry*
  • Models, Molecular
  • Periplasmic Binding Proteins / chemistry*
  • Siderophores / chemistry*

Substances

  • Coordination Complexes
  • Periplasmic Binding Proteins
  • Siderophores